| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7796338 | European Journal of Medicinal Chemistry | 2018 | 29 Pages |
Abstract
Stereoselective synthesis of novel spiroheterocyclic hybrids has been accomplished in [bmim]Br and were tested for anti-inflammatory activities. Compounds 4d, 4g, and 4o showed significant anti-inflammatory activities against acute and chronic inflammatory models. These compounds also showed significant inhibition of PGE2, TNF-α, and nitrite levels in carrageenan-induced hind paw oedema.245
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Authors
Raju Suresh Kumar, Paulrayer Antonisamy, Abdulrahman I. Almansour, Natarajan Arumugam, Govindasami Periyasami, Mohammad Altaf, Ha-Rim Kim, Kang-Beom Kwon,