Synthesis and characterization of nitrile functionalized silver(I)-N-heterocyclic carbene complexes: DNA binding, cleavage studies, antibacterial properties and mosquitocidal activity against the dengue vector, Aedes albopictus

A new series of benzimidazolium based nitrile-functionalized Ag(I)-N-heterocyclic carbene complexes was developed by the deprotonation of the benzimidazolium salts and refluxing the benzimidazolium salts in the presence of a slight excess of Ag2O. The most promising lead of this series, compound 8b, were highly larvicidal and adversely affected the development of larvae into adults at the tested concentrations.273