Structure-based design of bacterial transglycosylase inhibitors incorporating biphenyl, amine linker and 2-alkoxy-3-phosphorylpropanoate moieties

Article ID	Journal	Published Year	Pages	File Type
7796621	European Journal of Medicinal Chemistry	2018	77 Pages	PDF

Keywords

TGase LEU ATCC HOBt ASN FMOC PGM NBD MIC trimethylsilyl GlcNAc PBP PDB ASP A. baumannii MTG THF EDCI NCCLs transpeptidase Peptidoglycan monomer OPLC TPase MurNAc TMS ESI 2,2,2-trichloroethoxycarbonyl 7-nitrobenz-2-oxa-1,3-diazole N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide DMF 1-hydroxybenzotriazole 9-fluorenylmethoxycarbonyl DMSO N-acetylmuramic acid N,N-dimethylformamide S. aureus Arginine Asparagine Aspartic acid Arg Staphylococcus aureus glutamic acid Acinetobacter baumannii standard deviation isoleucine Ile Inhibitor Biphenyl Tetrahydrofuran Transglycosylase Tyr Tyrosine Minimal inhibitory concentration Troc Dimethylsulfoxide val Molecular sieves Leucine Lysine LYS Infrared American Type Culture Collection Moenomycin N-acetylglucosamine Valine optimized potentials for liquid simulations Penicillin-binding protein Protein Data Bank polyethyleneglycol PEG Peptidoglycan National Committee for Clinical Laboratory Standards Glu electrospray ionization

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Structure-based design of bacterial transglycosylase inhibitors incorporating biphenyl, amine linker and 2-alkoxy-3-phosphorylpropanoate moieties

Authors

Jui-Yin Yu, Hsiu-Jung Cheng, Huei-Ru Wu, Wei-Shen Wu, Jui-Wen Lu, Ting-Jen Cheng, Ying-Ta Wu, Jim-Min Fang,