Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor

Article ID	Journal	Published Year	Pages	File Type
7796676	European Journal of Medicinal Chemistry	2018	37 Pages	PDF

Abstract

Here we report the discovery of a small molecule (compound 1) that inhibits both Wnt (IC50â¯=â¯0.5â¯nM) and hedgehog (IC50â¯=â¯71â¯nM) pathways based on reporter gene assays.140

Keywords

BPO LRP WBC CSC BCC RBC STF SAR GPCR p.o.DVL2 i.v.PLT LyM SMO Red blood cells AUC DMSO H&E Antagonist Oral administration benzoyl peroxide clearance Hedgehog Dimethyl sulfoxide Structure–activity relationship Cancer therapy Stem cell Cancer stem cells Smoothened Pharmacokinetics Lymphocytes SEM Wnt signaling pathway Hedgehog signaling pathway Hematoxylin and Eosin Hemoglobin Hgb HCV Hepatitis C virus polymerase chain reaction PCR Low-density lipoprotein receptor-related protein Platelets Porcupine Ptch Patched Basal cell carcinoma white blood cells G protein-coupled receptor

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Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor

Authors

Haikuo Ma, Qin Chen, Fang Zhu, Jiyue Zheng, Jiajun Li, Hongjian Zhang, Shuaishuai Chen, Haimei Xing, Lusong Luo, Long Tai Zheng, Sudan He, Xiaohu Zhang,