Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled Î±-helical peptides with improved proteolytic stability

Article ID	Journal	Published Year	Pages	File Type
7796698	European Journal of Medicinal Chemistry	2018	35 Pages	PDF

Keywords

EC50 HCTU trifluorethanol Protein-protein interaction inhibitors SPPS Leishmania infantum TFE PPIs FCS IC50 CPP FITC RCM trypanothione reductase Enzyme-linked immunosorbent assay ELISA Protein-protein interactions Ring-closing metathesis Molecular dynamics circular dichroism fetal calf serum Solid phase peptide synthesis inhibitory concentration 50 effective concentration 50 fluorescein isothiocyanate Visceral leishmaniasis Propidium iodide polyethylene glycol PEG Cell-penetrating peptide cell-penetrating peptides Stapled peptides

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled Î±-helical peptides with improved proteolytic stability

Authors

Marta Ruiz-Santaquiteria, Sonia de Castro, Miguel A. Toro, Héctor de Lucio, Kilian Jesús Gutiérrez, Pedro A. Sánchez-Murcia, MarÃa Ángeles Jiménez, Federico Gago, Antonio Jiménez-Ruiz, MarÃa-José Camarasa, Sonsoles Velázquez,