| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7796725 | European Journal of Medicinal Chemistry | 2018 | 52 Pages |
Abstract
A series of amphiphilic η6-areneruthenium(II) compounds were synthesized, characterized, and their biological activity evaluated in human glioblastoma cell lines. Compound recognition by ABC transporters (P-gp, MRP1, and ABCG2) was investigated. Results evidenced that one of the cationic phenylazo-based η6-areneruthenium(II) compound was cytotoxic for all human glioblastoma cell lines tested, despite its transport by the three multidrug efflux proteins.232
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Authors
Jaqueline Pazinato, Otávio M. Cruz, Karine P. Naidek, Amanda R.A. Pires, Eduard Westphal, Hugo Gallardo, Hélène Baubichon-Cortay, Maria E.M. Rocha, Glaucia R. Martinez, Sheila M.B. Winnischofer, Attilio Di Pietro, Herbert Winnischofer,