| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7797102 | European Journal of Medicinal Chemistry | 2018 | 15 Pages |
Keywords
MTXM. tuberculosisextensively-drug resistantDihydrofolate reductase (DHFR)DMPKXDRtPSAMTBHBAHbdMDRnuclear magnetic resonancedhfrhydrogen bond donorsTuberculosisNMRdihydrofolate reductaseTopological polar surface areaTuberculosis (TB)selectivity indexdrug metabolism and pharmacokineticsMethotrexatemulti-drug resistanthydrogen bond acceptors
Related Topics
Physical Sciences and Engineering
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![1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity](/preview/png/7797102.png "First Page Preview: 1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity")
Authors
Xuan Yang, Wassihun Wedajo, Yoshiyuki Yamada, Sue-Li Dahlroth, Jason Jun-Long Neo, Thomas Dick, Wai-Keung Chui,