Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral Î²-lactam bridged combretastatin A-4 analogues as potent antitumor agents

Article ID	Journal	Published Year	Pages	File Type
7797203	European Journal of Medicinal Chemistry	2018	91 Pages	PDF

Abstract

A series of 3-substituted-1,4-diaryl-2-azetidinones were asymmetrically synthesized and SARs revealed that the stereochemistry were critically important for the antiproliferative activity.243

Keywords

TBAB DAPI PTX TBAF PARP PVDF FITC NMO H&E staining DMEM SAR Dulbecco minimum essential medium 1,4-diazabicyclo[2.2.2]octane 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide 4′,6-diamidino-2-phenylindole MTT Tetrabutylammonium bromide Tetrabutylammonium fluoride DABCO Structure-activity relationship hematoxylin-eosin staining Antitumor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)fluorescein isothiocyanate Pipes Paclitaxel Propidium iodide poly ADP-ribose polymerase Polyvinylidene fluoride Tubulin polymerization combretastatin A-4

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral Î²-lactam bridged combretastatin A-4 analogues as potent antitumor agents

Authors

Pengfei Zhou, Yuru Liang, Hao Zhang, Hao Jiang, Kechang Feng, Pan Xu, Jie Wang, Xiaoming Wang, Kuiling Ding, Cheng Luo, Mingming Liu, Yang Wang,