Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors

Article ID	Journal	Published Year	Pages	File Type
7797301	European Journal of Medicinal Chemistry	2018	12 Pages	PDF

Keywords

DMEM BnBr EDCI HOBt IKK PAGE RPMI TLC SDS SRB IC50 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride 50% inhibitory concentration Dulbecco's modified Eagle's medium N-hydroxybenzotriazole polyacrylamide gel electrophoresis Benzyl bromide Apoptosis sodium dodecyl sulfate sulforhodamine B Molecular dynamics simulation Roswell Park Memorial Institute HSP90 inhibitors Western blotting thin-layer chromatography Geldanamycin

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors

Authors

Chuanpeng Liang, Xingkang Wu, Zhenyu Li, Jing Zhu, Chunhua Lu, Yuemao Shen,