Design, synthesis, and biological evaluation of new 1,2,3-triazolo-2â²-deoxy-2â²-fluoro- 4â²-azido nucleoside derivatives as potent anti-HBV agents

Article ID	Journal	Published Year	Pages	File Type
7797322	European Journal of Medicinal Chemistry	2018	61 Pages	PDF

Abstract

A series of new 1,2,3-triazolo nucleosides have been designed and synthesized, with 1a being the most potent one against both wild-type and drug-resistant HBV strains.134

Keywords

SAR Nucleoside/Nucleotide Reverse Transcriptase Inhibitors NRTIs CC50 3TC HBsAg HBeAg LDT ETV FNC EC50 DHBV FQ-PCR CuAAC TLC PMEA Nucleoside reverse transcriptase inhibitor (NRTI)hepatitis Be antigen IFN-α 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 50% cytotoxic concentration 50% effective concentration MTT Hepatitis B surface antigen Entecavir Interferon-α Triphosphate telbivudine Viral DNA replication Molecular dynamics structure−activity relationship Anti-HBV activity Lamivudine HBV Hepatitis C virus HCV HIV Duck hepatitis B virus hepatitis B virus

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Design, synthesis, and biological evaluation of new 1,2,3-triazolo-2â²-deoxy-2â²-fluoro- 4â²-azido nucleoside derivatives as potent anti-HBV agents

Authors

Yuan Liu, Youmei Peng, Jingjing Lu, Jingwen Wang, Haoran Ma, Chuanjun Song, Bingjie Liu, Yan Qiao, Wenquan Yu, Jie Wu, Junbiao Chang,