How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitors

Article ID	Journal	Published Year	Pages	File Type
7797345	European Journal of Medicinal Chemistry	2017	21 Pages	PDF

Keywords

HER2 TMLR FDA TKIs GI50 Janus kinase 3 ERBB JAK3 RTK PIK3CA ADMET SAR IC50 PDB c-Met double mutant Structure-activity relationship Food and Drug Administration NSCLC Non-small cell lung cancer pharmacokinetic phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Casitas B-lineage lymphoma Resistance Tyrosine kinase inhibitors Irreversible inhibitors wild type half maximal inhibitory concentration Protein Data Bank Hydrogen bond Cbl Receptor Tyrosine Kinase Human epidermal growth factor receptor 2

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitors

Authors

Sandra N. Milik, Deena S. Lasheen, Rabah A.T. Serya, Khaled A.M. Abouzid,