Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents

Article ID	Journal	Published Year	Pages	File Type
7797392	European Journal of Medicinal Chemistry	2017	19 Pages	PDF

Keywords

RCC breakpoint cluster region-Abelson AML TMS ADME-Tox FDA OCTN1 VEGFR inhibitors absorption, distribution, metabolism, excretion, toxicity BCR-ABL OCT1 RTK VEGFR TKI VHL CML ABC EGFR PI3K MDR LRP HCC v-akt murine thymoma viral oncogene homolog adenosine 5′-triphosphate ATP Akt Von Hippel Lindau HER Drug combinations Gastrointestinal stromal tumor Tyrosine kinase RET organic cation transporter 1 nucleotide-binding domains Transmembrane domains Rearranged during transfection Food and Drug Administration Non small cell lung cancer NSCLC phosphoinositide-3-kinase acute myeloid leukemia Acute lymphoblastic leukemia Chronic myeloid leukemia Gist Multi-drug resistance EGFR inhibitors Tyrosine kinase inhibitors ALL low density lipoprotein receptor-related protein Renal cell carcinoma Hepatocellular carcinoma ATP binding cassette receptor tyrosine kinases vascular endothelial growth factor receptor Epidermal growth factor receptor

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Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents

Authors

Giovanni Luca Beretta, Giuliana Cassinelli, Marzia Pennati, Valentina Zuco, Laura Gatti,