Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2

Twenty-seven aryl C-glycosides, whose glycone is a 6-amino-/6-imino-6-deoxy-β-d-glucosyl group, were synthesized. Biological, pharmacokinetic and efficacy studies culminated in the identification of oxime 2a as a potential SGLT2 inhibitor.132