New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

Article ID	Journal	Published Year	Pages	File Type
7797613	European Journal of Medicinal Chemistry	2016	21 Pages	PDF

Keywords

CREB CR3 SAR GPCRs pKa cGMP PDE cAMP G protein coupled receptors Cyclic adenosine monophosphate Alzheimer disease COPD Chronic obstructive pulmonary disease long term potentiation LTP Structure-activity-relationship Molecular dynamics simulation Molecular dynamics simulations correlation spectroscopy Phosphodiesterase PDE4 inhibitors cyclic guanosine monophosphate cAMP response element-binding protein protein kinase A COSY

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Preview

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

Authors

Chiara Brullo, Roberta Ricciarelli, Jos Prickaerts, Ottavio Arancio, Matteo Massa, Chiara Rotolo, Alessia Romussi, Claudia Rebosio, Barbara Marengo, Maria Adelaide Pronzato, Britt T.J. van Hagen, Nick P. van Goethem, Pasqualina D'Ursi, Alessandro Orro,