| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7797614 | European Journal of Medicinal Chemistry | 2016 | 14 Pages |
Abstract
A series of xanthine derivatives targeting DPP-IV and GPR119 was designed and synthesized through the pharmacophore merging strategy. Systematic optimization of general structure led to the identification of dual modulator 20i with selective DPP-IV inhibition, good GPR119 agonism activity and favorable metabolic stability.195
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gang Li, Yi Huan, Baokun Yuan, Jin Wang, Qian Jiang, Ziyun Lin, Zhufang Shen, Haihong Huang,