Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7797619 | European Journal of Medicinal Chemistry | 2016 | 57 Pages |
Abstract
New series of indazole-based derivatives were synthesized and structure-activity relationship was constructed. Hit compound from sub-structure search, followed by in silico fragment-based drug design and knowledge-based drug design to discover compound 17 as a potent novel Aurora kinases inhibitor.212
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chun-Feng Chang, Wen-Hsing Lin, Yi-Yu Ke, Yih-Shyan Lin, Wen-Chieh Wang, Chun-Hwa Chen, Po-Chu Kuo, John T.A. Hsu, Biing-Jiun Uang, Hsing-Pang Hsieh,