Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings

In this paper, a series of catecholamides bearing aromatic rings was designed and synthesized as PDE4 inhibitors. Among these compounds, compound 7j with anti-neuroinflammation activity showed preference for PDE4 with higher selectivity over other PDEs.198