Analogue based drug design, synthesis, molecular docking and anticancer evaluation of novel chromene sulfonamide hybrids as aromatase inhibitors and apoptosis enhancers

Twenty novel chromene derivatives carrying biologically active sulfonamide scaffold (3-22) were designed and synthesized ➨ Antiproliferative activity against T47D cell line ➨ Aromatase inhibitory activity ➨ Induction of both extrinsic and intrinsic pathways ➨ Cytotoxicity study on normal breast cells ➨ Cell cycle arrest at G2/M phase.140