Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors

Article ID	Journal	Published Year	Pages	File Type
7797783	European Journal of Medicinal Chemistry	2016	9 Pages	PDF

Keywords

IC50 TDO HEK293T LLC ALA RT-PCR GAPDH human embryonic kidney 293T IDO1 PDB IPTG Trp PBS DMEM FBS SNPs SEC FDA DMSO EDTA ethylene diamine tetraacetic acid δ-aminolevulinic acid sodium dodecyl sulfate–polyacrylamide gel electrophoresis SDS-PAGE Indoleamine 2 isopropyl β-D-1-thiogalactopyranoside Tryptophan Dimethyl sulfoxide Food and Drug Administration Lewis lung cancer fetal bovine serum Phosphate buffered saline Dulbecco’s modified eagle’s medium half-maximum inhibitory concentration reverse transcription polymerase chain reaction Molecular weight Protein Data Bank Size exclusion chromatography glyceraldehyde-3-phosphate dehydrogenase

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors

Authors

Juanjuan Li, Yang Li, Dan Yang, Nan Hu, Zhanling Guo, Chunxiang Kuang, Qing Yang,