| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7797819 | European Journal of Medicinal Chemistry | 2016 | 35 Pages |
Abstract
A series of tacrine-based pyrazolo[4â²,3â²:5,6]pyrano[2,3-b]quinolines and related compounds were synthesized for targeting AChE, BuChE and 15-LOX without cytotoxic activity against on HepG2 cells. Most of compounds showed potent activity against cholinesterases and mild potency toward 15-LOX enzyme.216
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Organic Chemistry
![Synthesis and structure-activity relationship study of tacrine-based pyrano[2,3-c]pyrazoles targeting AChE/BuChE and 15-LOX](/preview/png/7797819.png "First Page Preview: Synthesis and structure-activity relationship study of tacrine-based pyrano[2,3-c]pyrazoles targeting AChE/BuChE and 15-LOX")
Authors
Ladan Pourabdi, Mehdi Khoobi, Hamid Nadri, Alireza Moradi, Farshad Homayouni Moghadam, Saeed Emami, Mohammad M. Mojtahedi, Ismaeil Haririan, Hamid Forootanfar, Alieh Ameri, Alireza Foroumadi, Abbas Shafiee,