Synthetic, enzyme kinetic, and protein crystallographic studies of C-Î²-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase

Article ID	Journal	Published Year	Pages	File Type
7797979	European Journal of Medicinal Chemistry	2016	36 Pages	PDF

Keywords

Glycogen phosphorylase inhibitor Indole Imidazole Diabetes type 2 Pyrrole

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Synthetic, enzyme kinetic, and protein crystallographic studies of C-Î²-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase

Authors

Anastassia L. Kantsadi, Ãva Bokor, Sándor Kun, George A. Stravodimos, Demetra S.M. Chatzileontiadou, Demetres D. Leonidas, Ãva Juhász-Tóth, Andrea Szakács, Gyula Batta, Tibor Docsa, Pál Gergely, László Somsák,