Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening

Article ID	Journal	Published Year	Pages	File Type
7798365	European Journal of Medicinal Chemistry	2016	44 Pages	PDF

Keywords

TOCSY Pan-Assay Interference Compounds T-L PGPH ChT-L SBVS NOE HSQC AmC RPMI PBS SAR NCI 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 7-amino-4-methylcoumarin DMSO MTT nuclear overhauser effect PAINS Dimethylsulfoxide Structure-activity relationship Virtual screening Structure-based virtual screening Non-covalent Phosphate buffered saline Trypsin-like Chymotrypsin-like Docking studies Proteasome inhibitors Roswell Park Memorial Institute medium National Cancer Institute Multiple myeloma HMBC یا Heteronuclear Multiple Bond Correlation heteronuclear single-quantum coherence

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening

Authors

Carmen Di Giovanni, Roberta Ettari, Serena Sarno, Archimede Rotondo, Alessandra Bitto, Francesco Squadrito, Domenica Altavilla, Tanja Schirmeister, Ettore Novellino, Silvana Grasso, Maria ZappalÃ , Antonio Lavecchia,