Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7798389 | European Journal of Medicinal Chemistry | 2016 | 40 Pages |
Abstract
New 1-(4-(aryl(methyl)amino)butyl)-heterocyclic derivatives were designed and synthesized in order to evaluate their affinity towards Ï receptors by radioligand binding assays. Moreover, in order to investigate their cytotoxic activity, a functional assay was performed. Some of these derivatives showed a remarkable affinity and selectivity towards Ï1 receptors and an interesting cytotoxic profile.96
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Authors
Daniele Zampieri, Luciano Vio, Maurizio Fermeglia, Sabrina Pricl, Bernhard Wünsch, Dirk Schepmann, Maurizio Romano, Maria Grazia Mamolo, Erik Laurini,