5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

Article ID	Journal	Published Year	Pages	File Type
7798465	European Journal of Medicinal Chemistry	2016	54 Pages	PDF

Keywords

EGFR Phenyl arsine oxide PIFA tetramethylsilane ECACC TMZ P-gp GBM ATCC HRMS MGMT DAPI O6-Methylguanine-DNA-methyltransferase TMS TLC DSMZ SAR PAO MDR DMF DMEM FBS 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 4′,6-diamidino-2-phenylindole DMSO Dulbecco's modified Eagle's medium MTT P-glycoprotein Podophyllotoxin standard deviation Temozolomide dimethylformamide Dimethyl sulfoxide Structure-activity relationship NSCLC Non-small cell lung cancer fetal bovine serum High resolution mass spectrometry Lycorine American Type Culture Collection Apoptosis resistance Multidrug resistance Translation inhibition Haemanthamine thin layer chromatography Glioblastoma multiforme Glioblastoma Epidermal growth factor receptor

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

Authors

Sean Henry, Ria Kidner, Mary R. Reisenauer, Igor V. Magedov, Robert Kiss, Véronique Mathieu, Florence Lefranc, Ramesh Dasari, Antonio Evidente, Xiaojie Yu, Xiuye Ma, Alexander Pertsemlidis, Regina Cencic, Jerry Pelletier, David A. Cavazos,