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Novel double prodrugs of the iron chelator N,N′-bis(2-hydroxybenzyl)ethylenediamine-N,N′-diacetic acid (HBED): Synthesis, characterization, and investigation of activation by chemical hydrolysis and oxidation

Article ID Journal Published Year Pages File Type
7798544 European Journal of Medicinal Chemistry 2016 15 Pages PDF
Keywords
FACDFONMMN-methylmorpholineHBEDROSIronFerric Ammonium CitrateEDTAEthylenediaminetetraacetic acidBoronic acidOxidative stressChelation therapyDesferrioxamine BReactive oxygen species
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
Novel double prodrugs of the iron chelator N,N′-bis(2-hydroxybenzyl)ethylenediamine-N,N′-diacetic acid (HBED): Synthesis, characterization, and investigation of activation by chemical hydrolysis and oxidation
Authors
Nikki A. Thiele, Khalil A. Abboud, Kenneth B. Sloan,
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Journal
European Journal of Medicinal Chemistry
Journal: European Journal of Medicinal Chemistry
Related Categories
FAC
DFO
NMM
N-methylmorpholine
HBED
ROS
Iron
Ferric Ammonium Citrate
EDTA
Ethylenediaminetetraacetic acid
Boronic acid
Oxidative stress
Chelation therapy
Desferrioxamine B
Reactive oxygen species
Analytical Chemistry
Chemistry (General)
Electrochemistry
Inorganic Chemistry
Organic Chemistry
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