Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases

Article ID	Journal	Published Year	Pages	File Type
7798610	European Journal of Medicinal Chemistry	2016	12 Pages	PDF

Keywords

DMAP Wnt PARP mESC ADP MTS HSQC TRF1 4-dimethylaminopyridine Cbz NUMA THF TNKS EDC (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium)nuclear mitotic apparatus protein nuclear magnetic resonance adenosine diphosphate Electrospray Benzyl benzyloxycarbonyl Tankyrase Tetrahydrofuran NMR Hydrophobic cavity Mouse embryonic stem cell Heteronuclear single quantum coherence spectroscopy heteronuclear multiple-bond correlation spectroscopy NAD nicotinamide adenine dinucleotide HMBC یا Heteronuclear Multiple Bond Correlation poly(ADP-ribose)polymerase Poly(ethyleneglycol)PEG

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Preview

Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases

Authors

Amit Nathubhai, Teemu Haikarainen, Penelope C. Hayward, Silvia Muñoz-Descalzo, Andrew S. Thompson, Matthew D. Lloyd, Lari Lehtiö, Michael D. Threadgill,