Structural requirements of acylated Gly-l-Ala-d-Glu analogs for activation of the innate immune receptor NOD2

Article ID	Journal	Published Year	Pages	File Type
7798662	European Journal of Medicinal Chemistry	2016	12 Pages	PDF

Keywords

SAR MurNAc Immunoadjuvant dicyclohexylcarbodiimide LRR SEAP MDP RIP2 muramyl dipeptide NLR HOBt PRR DCC TLR NF-κB MTS NOD TFA 4-dimethylaminopyridine EDC DMAP 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide 1-hydroxybenzotriazole MAPK secreted embryonic alkaline phosphatase Trifluoroacetic acid Immunostimulant Immunomodulator Leucine-rich repeats Toll-like receptor nucleotide-binding oligomerization domain Structure/activity relationship nuclear factor κB caspase activation and recruitment domain mitogen-activated protein kinase CARD Nod-like receptor pattern recognition receptors

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Structural requirements of acylated Gly-l-Ala-d-Glu analogs for activation of the innate immune receptor NOD2

Authors

Martina Gobec, Irena MlinariÄ-RaÅ¡Äan, Marija Sollner Dolenc, Å½iga Jakopin,