| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7798744 | European Journal of Medicinal Chemistry | 2016 | 31 Pages |
Abstract
Steroidal hybrids were synthesized and evaluated for their antiproliferative activity. Compound 12g potently inhibited growth of SH-SY5Y cells possibly through the inactivation of LSD1, arrested cell cycle at G2/M phase, induced apoptosis and decreased MMP. Docking simulations were performed to rationalize the potency toward LSD1.229
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bin Yu, Ping-Ping Qi, Xiao-Jing Shi, Ruilei Huang, Hao Guo, Yi-Chao Zheng, De-Quan Yu, Hong-Min Liu,