Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups

Article ID	Journal	Published Year	Pages	File Type
7798757	European Journal of Medicinal Chemistry	2016	17 Pages	PDF

Keywords

DMF S1PR3 O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate PPh3 BuLi S1P1 receptor agonist MECN NMP RLM S1PR1 TBTU FUP HOBt S1P LC-MS TFA THF EDC SAR DCM 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide N-hydroxybenzotriazole Ethyl acetate Acetonitrile sphingosine 1-phosphate Trifluoroacetic acid Immunomodulator Tetrahydrofuran Triphenylphosphine Lymphocyte count diethyl azodicarboxylate diisopropylethylamine dimethylformamide Dichloromethane Structure-activity relationship Pharmacokinetics Phototoxicity Methanol DEAD MeOH Rat liver microsomes DIPEA Column chromatography

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups

Authors

Cyrille Lescop, Claus Müller, Boris Mathys, Magdalena Birker, Ruben de Kanter, Christopher Kohl, Patrick Hess, Oliver Nayler, Markus Rey, Patrick Sieber, Beat Steiner, Thomas Weller, Martin H. Bolli,