Dihydropyrazole derivatives as telomerase inhibitors: Structure-based design, synthesis, SAR and anticancer evaluation in vitro and in vivo

Based on structure-based drug design, 78 compounds as potential human telomerase inhibitors were designed. In vivo studies showed that compound 13i displayed potent anticancer activity with inhibition tumor growth of S180 and HepG2 tumor-bearing mice. It also significantly enhanced the survival rate of EAC tumor-bearing mice.259