8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties

Article ID	Journal	Published Year	Pages	File Type
7798956	European Journal of Medicinal Chemistry	2016	11 Pages	PDF

Keywords

DTPA Redox activation SAR ESI NADPH-cytochrome P450 oxidoreductase NQO-1 DCC 4-dimethylaminopyridine DMAP APCI NAD(P)H:quinone oxidoreductase 1 N,N′-dicyclohexylcarbodiimide ROS CPR diethylene triamine pentaacetic acid supporting information Room temperature dihydroethidium Structure–activity relationship superoxide radical SOD HaCaT cells Superoxide dismutase Mass spectrometry Antiproliferative activity lactate dehydrogenase LDH DHE Quinone Reactive oxygen species electrospray ionization electron ionization atmospheric pressure chemical ionization

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties

Authors

Cathrin Lindenschmidt, Dirk Krane, Silke Vortherms, Lars Hilbig, Helge Prinz, Klaus Müller,