Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1

Article ID	Journal	Published Year	Pages	File Type
7799003	European Journal of Medicinal Chemistry	2015	129 Pages	PDF

Keywords

SAR IC50 EC50 cdk5 GSK3 Imidazo[1,2-b]pyridazine HFF CK1 Ripk3 CC50 50% cytotoxic concentration 50% inhibitory concentration 50% effective concentration Toxoplasma gondii Structure-activity relationships cyclin-dependent kinase 5 human foreskin fibroblasts Receptor-interacting Protein Kinase 3 casein kinase 1 glycogen synthase kinase 3

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1

Authors

Espérance Moine, Isabelle Dimier-Poisson, Cécile Enguehard-Gueiffier, Cédric Logé, Mélanie Pénichon, Nathalie Moiré, Claire Delehouzé, Béatrice Foll-Josselin, Sandrine Ruchaud, Stéphane Bach, Alain Gueiffier, Françoise Debierre-Grockiego,