Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

Article ID	Journal	Published Year	Pages	File Type
7799064	European Journal of Medicinal Chemistry	2015	15 Pages	PDF

Keywords

PI3K GBM GSK3 PDK1 Chk1 GSCs Multi-target therapy Oxindole derivatives Akt phosphatidylinositol-3-kinase Kinase inhibitors Phosphoinositide-dependent kinase-1 protein kinase B Glioblastoma glycogen synthase kinase 3

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

Authors

Simona Sestito, Giulia Nesi, Simona Daniele, Alma Martelli, Maria Digiacomo, Alice Borghini, Daniele Pietra, Vincenzo Calderone, Annalina Lapucci, Marco Falasca, Paola Parrella, Angelantonio Notarangelo, Maria C. Breschi, Marco Macchia, Claudia Martini,