Design, synthesis, and biological evaluation of new N4-Substituted 2′-deoxy-2′-fluoro-4′-azido cytidine derivatives as potent anti-HBV agents

A series of new N4-substituted 2′-deoxy-2′-β-fluoro-4′-azido-β-d-arabinofuranosyl cytidines were designed and synthesized, with analog 1g found to possess significant inhibitory activity on both secretion of HBV antigens and replication of the viral DNA.105