Structure-activity relationship study using peptide arrays to optimize Api137 for an increased antimicrobial activity against Pseudomonas aeruginosa

Article ID	Journal	Published Year	Pages	File Type
7799315	European Journal of Medicinal Chemistry	2015	9 Pages	PDF

Keywords

TIS HOBt TFA 4-dimethylaminopyridine MIC TSB DMAP HBTU NMM DIC AMP HMBA N-methylimidazole N-methylmorpholine N,N,N′,N′-tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate PBS SAR 1-hydroxy-benzotriazole l-Ornithine MHb MTT Nmi N,N′-diisopropylcarbodiimide Apidaecin Trifluoroacetic acid Gram-negative bacterium Minimal inhibitory concentration Structure activity relationship SPOT synthesis Pseudomonas aeruginosa Tryptic soy broth Phosphate buffered saline lactate dehydrogenase LDH methylthiazolyldiphenyl-tetrazolium bromide Mueller Hinton Broth NADH DIPEA Antimicrobial peptide

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Structure-activity relationship study using peptide arrays to optimize Api137 for an increased antimicrobial activity against Pseudomonas aeruginosa

Authors

Martina E.C. Bluhm, Daniel Knappe, Ralf Hoffmann,