| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7799379 | European Journal of Medicinal Chemistry | 2015 | 14 Pages |
Abstract
A library of 20 new tetrahydropyrido[1,2-a]isoindolone derivatives were designed and evaluated against protein kinases . Several derivatives inhibit strongly CDK5 and GSK3. Among them, compound 29 has exhibited excellent activity against the seven tested human cell lines.206
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Rajâa Boulahjar, Aziz Ouach, Stéphane Bourg, Pascal Bonnet, Olivier Lozach, Laurent Meijer, Christiane Guguen-Guillouzo, Rémy Le Guevel, Saïd Lazar, Mohamed Akssira, Yves Troin, Gérald Guillaumet, Sylvain Routier,