Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2

Article ID	Journal	Published Year	Pages	File Type
7799426	European Journal of Medicinal Chemistry	2015	8 Pages	PDF

Keywords

SAR LPS COX PGHS QED TRIS CH3OH Phorbol-12-myristate-13-acetate tPSA PGE2 TLC GAPDH RMSD PDB DMSO PMA enzyme immuno assay enzyme linked immunosorbent assay EDTA Ethylenediaminetetraacetic acid EIA Genetic Optimization for Ligand Docking Tris(hydroxymethyl)-aminomethane ELISA Dimethylsulfoxide Structure activity relationship Molar refractivity BCs Topological polar surface area biopharmaceutics classification system Gold lipopolysaccharide Methanol Molecular weight Protein Data Base Prostaglandin E2 Prostaglandin H synthase thin layer chromatography glycerinaldehyde-3-phosphate dehydrogenase

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Preview

Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2

Authors

Werner Seebacher, Johanna Faist, Armin Presser, Robert Weis, Robert Saf, Teresa Kaserer, Veronika Temml, Daniela Schuster, Sabine Ortmann, Nadine Otto, Rudolf Bauer,