| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7799429 | European Journal of Medicinal Chemistry | 2015 | 11 Pages |
Abstract
We synthesized novel curcumin analogues with antioxidant and anticancer activities. Compound 7h showed remarkable activity having 82.60% inhibition of the ABTS radical cation, 100% death of cultured EAC cells and 82% tumor growth inhibition. Also docking studies showed that compound 7h is well fitted in the active site of telomerase enzyme with Gln B367, Lys B169 and Asn B303 aminoacid residues.163
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Authors
Said M. Bayomi, Hassan A. El-Kashef, Mahmoud B. El-Ashmawy, Magda N.A. Nasr, Magda A. El-Sherbeny, Naglaa I. Abdel-Aziz, Magda A.-A. El-Sayed, Ghada M. Suddek, Shahenda M. El-Messery, Mariam A. Ghaly,