| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7799637 | European Journal of Medicinal Chemistry | 2015 | 49 Pages |
Abstract
Twenty-five betulonic acid derivatives were designed and synthesized and found to possess good antiproliferative activities against five cell lines, among which compound 3k was found to induce cell apoptosis on MGC-803 cells through the mitochondrial intrinsic pathway.
Keywords
DMFterminal deoxynucleotidyl transferase biotin-dUTP nick end labelingEDCIHCPTHOBtADM1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride1-hydroxybenzotriazole1H NMR3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideAO/EBDMSOMTTN, N-dimethylformamideAdriamycinacridine orange/ethidium bromideBetulonic acidBETATUNELApoptosisDimethyl sulfoxide13C nuclear magnetic resonance13C NMRSynthesisAntitumorInfra-redMitochondrial pathwayproton nuclear magnetic resonance
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sheng-Jie Yang, Ming-Chuan Liu, Qi Zhao, De-Yu Hu, Wei Xue, Song Yang,