| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7799831 | European Journal of Medicinal Chemistry | 2015 | 36 Pages |
Abstract
Compound 4a (general formula B; R = H) has IC50 of 0.72 and 0.50 μM against MCF-7 and A-549 cells, respectively. It has Ki of 29.75 and 4.54 nM on hCA IX and XII, respectively. It raises the % of early apoptotic cells to 94.12 and 74.77% in breast and lung cells, respectively.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fadi M. Awadallah, Tamer A. El-Waei, Mona M. Hanna, Safinaz E. Abbas, Mariangela Ceruso, Beyza Ecem Oz, Ozen Ozensoy Guler, Claudiu T. Supuran,