| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7799976 | European Journal of Medicinal Chemistry | 2015 | 17 Pages |
Abstract
A series of pyrazole phenylcyclohexylcarbamate derivatives standing on the known carbamoyl FAAH inhibitor URB597 was prepared. The most active compounds of this series showed significant selectivity toward monoacylglycerol lipase (MAGL) enzyme. Among the screened compounds, the 3-(3-(ethoxycarbonyl)-1-phenyl-1H-pyrazol-5-yl)phenyl cyclohexylcarbamate (22) showed high inhibitor activity (IC50Â =Â 11Â nM).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mojgan Aghazadeh Tabrizi, Pier Giovanni Baraldi, Emanuela Ruggiero, Giulia Saponaro, Stefania Baraldi, Romeo Romagnoli, Adriano Martinelli, Tiziano Tuccinardi,