Discovery of HCV NS5B thumb site I inhibitors: Core-refining from benzimidazole to indole scaffold

Article ID	Journal	Published Year	Pages	File Type
7800082	European Journal of Medicinal Chemistry	2015	11 Pages	PDF

Abstract

Discovery and development of indole analogues as HCV NS5B thumb site I inhibitors were reviewed.

Keywords

HTS RVB SVR RdRp DAAs HCC standard of care Indole DOS Structure-activity relationships Ribavirin SARS World Health Organization Diversity-oriented synthesis SOC Anti-viral direct-acting antiviral agents high throughput screening Heterocycle Hepatitis C virus HCV sustained virological response Hepatocellular carcinoma WHO

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Discovery of HCV NS5B thumb site I inhibitors: Core-refining from benzimidazole to indole scaffold

Authors

Fabao Zhao, Na Liu, Peng Zhan, Xuemei Jiang, Xinyong Liu,