Structure-activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway

Article ID	Journal	Published Year	Pages	File Type
7800232	European Journal of Medicinal Chemistry	2015	136 Pages	PDF

Keywords

DMF MTD GSK GBM LTQ APC MDCK frizzled TOF UPLC TCF PAMPA B/P TLC ACN LRP ESI MPSA CDI DCM LHS SAR RHS DMSO adenomatous polyposis coli Acetonitrile β-catenin Reporter gene assay Parallel artificial membrane permeability assay Linear trap quadrupole Maximum tolerated dose CNS dimethylsulphoxide dimethylformamide Dichloromethane Structure-activity relationship Structure–activity relationship Rga Retention time Time-of-Flight right hand side left hand side central nervous system Mass spectrometry Madin Darby canine kidney Wnt pathway Small molecule HATU Lipoprotein receptor-related protein thin layer chromatography liquid chromatography ultra performance liquid chromatography High pressure liquid chromatography HPLC Glioblastoma multiforme Glioblastoma glycogen synthase kinase electrospray ionization

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Structure-activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway

Authors

Arianna Nencini, Carmela Pratelli, Joanna M. Quinn, Massimiliano Salerno, Patrizia Tunici, Alessandra De Robertis, Silvia Valensin, Federica Mennillo, Marco Rossi, Annette Bakker, Tiziana Benicchi, Federico Cappelli, Elisa Turlizzi, Martina Nibbio,