Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives with dual p38αMAPK and ERK1/2 inhibitory activity

6d (R = 3-OCH3, R1 = 4-CH3)and 7h (R = 4-OCH3, R1 = 2-Cl) exert inhibitory activity of 4.5 and 4.7 nM against p38αMAP, 25 and 24 nM against ERK1, and 3.2 and 3.5 nM against ERK2, respectively.