Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity

Hybrid molecules containing a combretastatin A-4 and a pironetin analogue moiety connected through a spacer of variable length which includes a 1,2,3-triazole ring have been prepared. The cytotoxic activities of these compounds have been measured. Relations between structure and cytotoxicity are discussed. Compound 8 proved comparatively much less cytotoxic towards normal cells than to the HT-29 tumoral cell line.