A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness

Article ID	Journal	Published Year	Pages	File Type
7800588	European Journal of Medicinal Chemistry	2014	14 Pages	PDF

Keywords

STAT3 Dulbeco's modified Eagle's medium Growth arrest-specific 6 FSB Panc-1 cells CDK4 Bcl-xL IAP HIF-1α PMSF Bcl-2 Mcl-1 GSH DMEM PARP-1 GAPDH Cdk6 ERK1/2 MTT ROS Axl Bax myeloid cell leukemia sequence 1 Pancreatic cancer cyclin-dependent kinase 6 hypoxia-inducible factor-1α Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Hydrogen fluoride Phenylmethanesulfonyl fluoride B-cell lymphoma-extra large inhibitor of apoptosis proteins Bcl-2-associated X protein retinoblastoma protein poly (ADP-ribose) polymerase extracellular signal-regulated kinases 1 and 2 cyclin-dependent kinase 4 Gas6 Glutathione glyceraldehyde-3-phosphate dehydrogenase Reactive oxygen species goniothalamin

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Physical Sciences and Engineering Chemistry Organic Chemistry

A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness

Authors

Rosimeire Coura Barcelos, Karin Juliane Pelizzaro-Rocha, Julio Cezar Pastre, Marina Pereira Dias, Carmen VerÃssima Ferreira-Halder, Ronaldo Aloise Pilli,