| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7800593 | European Journal of Medicinal Chemistry | 2014 | 45 Pages |
Abstract
A series of 3,6-diphenylimidazo[2,1-b]thiazol-5-amines containing bulky 5-alkylamino residues were synthesized as 15-lipoxygenase inhibitors. The most active compound 5i bearing 5-(2,4,4-trimethylpentan-2-ylamino) group was 2-fold more potent than reference drug quercetin.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Imidazo[2,1-b]thiazole derivatives as new inhibitors of 15-lipoxygenase](/preview/png/7800593.png "First Page Preview: Imidazo[2,1-b]thiazole derivatives as new inhibitors of 15-lipoxygenase")
Authors
Maliheh Barazandeh Tehrani, Saeed Emami, Mehdi Asadi, Mina Saeedi, Mohammadreza Mirzahekmati, Seyyed Mostafa Ebrahimi, Mohammad Mahdavi, Hamid Nadri, Alireza Moradi, Farshad Homayouni Moghadam, Soghra Farzipour, Mohsen Vosooghi, Alireza Foroumadi,