Design and synthesis of novel 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazol-3-yl)pyridines as potential antitumor agents

A series of 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazole-3-yl)pyridine derivatives were synthesized. These analogs demonstrated potent antitumor potency and good enzyme selectivity, many of them could be served as promising candidates for further development.