| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7800682 | European Journal of Medicinal Chemistry | 2014 | 13 Pages |
Abstract
Tamiphosphor monoester 3f fits the binding pocket of influenza neuraminidase with the phenylpropyl group embedded in the 371-cavity near the S1-site.
Keywords
CC50MDCKi.v.DMEMCPELD50GOSi.p.TCID50HBTUEC50IC50GOCAUCDulbecco's modified Eagle MediumInfluenzaEDTAEthylenediaminetetraacetic acidCytopathic effectOseltamivirInhibitorclearanceintraperitonealIntravenousPartition coefficientDistribution coefficientPharmacokineticsMolecular modelingMUNANAmedian lethal doseneuraminidasehalf maximal inhibitory concentrationhalf maximal effective concentrationVirusMadin–Darby Canine Kidney
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chun-Lin Chen, Tzu-Chen Lin, Shi-Yun Wang, Jiun-Jie Shie, Keng-Chang Tsai, Yih-Shyun E. Cheng, Jia-Tsrong Jan, Chun-Jung Lin, Jim-Min Fang, Chi-Huey Wong,