| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7801892 | European Journal of Medicinal Chemistry | 2013 | 14 Pages |
Abstract
We combined the click chemistry and in situ screening technologies to fast explore the SAR of C terminus of our previous compound. Further modification identified the pyrazole group as a good substituent for BACE1 inhibitors in the enzymatic, cellular inhibition assays.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yiquan Zou, Lei Xu, Wuyan Chen, Yiping Zhu, Tiantian Chen, Yan Fu, Li Li, Lanping Ma, Bing Xiong, Xin Wang, Jian Li, Jianhua He, Haiyan Zhang, Yechun Xu, Jia Li, Jingkang Shen,